About the author Ana Garcia

A molecular view of DNA flexibility

No te pierdas la revisión del grupo de nuestro coordinador Fernando Moreno-Herrero sobre los conocimientos que se pueden obtener de las propiedades mecánicas del DNA con experimentos de molécula única y simulaciones de dinámica molecular.

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Type VII secretion systems: structure, functions and transport models

Angel Rivera-Calzada, Nikolaos Famelis, Oscar Llorca & Sebastian Geibel

Abstract: Type VII secretion systems (T7SSs) have a key role in the secretion of effector proteins in non-pathogenic mycobacteria and pathogenic mycobacteria such as Mycobacterium tuberculosis, the main causative agent of tuberculosis. Tuberculosis-causing mycobacteria, still accounting for 1.4 million deaths annually, rely on paralogous T7SSs to survive in the host and efficiently evade its immune response. Although it is still unknown how effector proteins of T7SSs cross the outer membrane of the diderm mycobacterial cell envelope, recent advances in the structural characterization of these secretion systems have revealed the intricate network of interactions of conserved components in the plasma membrane. This structural information, added to recent advances in the molecular biology and regulation of mycobacterial T7SSs as well as progress in our understanding of their secreted effector proteins, is shedding light on the inner working of the T7SS machinery. In this Review, we highlight the implications of these studies and the derived transport models, which provide new scenarios for targeting the deathly human pathogen M. tuberculosis.

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Buenas noticias: NanoBioCancer continuará en 2021

Teniendo en cuenta los buenos resultados científicos del consorcio, correspondientes al primer periodo de ejecución de la ayuda, se ha propuesto la continuación del proyecto NanoBioCancer-CM (Ref. Y2018/BIO-4747) para la tercera anualidad. ¡Enhorabuena por el trabajo a tod@s!